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Please only add bosses once you have confirmed what floor they are on (hold TAB in-game if you are uncertain). Do NOT assume bosses appear in the same areas as they did in the original Isaac. Unconfirmed bosses have asterisks around their name.

Bosses are strong monsters found in boss rooms at the end of a floor. The boss at the end of the floor must be defeated in order to advance to the next floor. In later chapters, bosses are able to spawn as normal enemies. The boss for a particular floor is chosen from the pool of bosses for the environment of the floor. Bosses may also spawn as champions, which can change various attributes such as health, damage, and attack pattern. Upon defeat, most bosses will drop an item from the boss item pool. Additionally, some floors may spawn a room with a Mini-Boss.

Chapter 1Edit

The BasementEdit

Boss Monstro Boss Gemini Boss Steven
Monstro Gemini Steven

The CellarEdit

Boss Gurdy Jr. Boss Pin
Boss Widow
Boss Blighted Ovum
Boss The Haunt
Gurdy Jr. Pin Widow Blighted Ovum The Haunt

The Basement and The CellarEdit

Boss Dingle
Boss Larry Jr.
Boss The Duke of Flies
Boss Famine
Boss Gurglings
Boss Fistula
Dingle Larry Jr. The Duke of Flies Famine Gurglings Fistula

Chapter 2Edit

The CavesEdit

Boss Chub
Boss Gurdy
Boss Gurdy Jr.
Chub Gurdy Gurdy Jr.
Boss Mega Maw
Boss Mega Fatty
Boss C.H.A.D.
Mega Maw Mega Fatty C.H.A.D.

Double TroubleEdit

Boss Blighted Ovum
Boss The Duke of Flies
Boss Mega Fatty
Boss Monstro
(Double Trouble)

Blighted Ovum

(Double Trouble)

The Duke of Flies

(Double Trouble)

Mega Fatty

(Double Trouble)

Monstro

The CatacombsEdit

Boss The Hollow
Boss The Husk
Boss Peep
The Hollow The Husk Peep
Boss Polycephalus
Boss The Carrion Queen
Boss The Wretched
Polycephalus The Carrion Queen The Wretched

Double TroubleEdit

Boss Dingle
Boss The Duke of Flies
Boss Gemini
Boss Widow
Boss Gurdy Jr.
Boss Pin
Boss Polycephalus
Boss Larry Jr.
(Double Trouble)

Dingle

(Double Trouble)

The Duke of Flies

(Double Trouble)

Gemini

(Double Trouble)

Widow

(Double Trouble)

Gurdy Jr.

(Double Trouble)

Pin

(Double Trouble)

Polycephalus

(Double Trouble)

Larry Jr.

The Caves and The CatacombsEdit

Boss Dark One
Boss Pestilence
Dark One Pestilence

Chapter 3Edit

Floor 1Edit

The DepthsEdit

Boss The Cage
Boss Monstro II
Boss The Adversary
Boss Gish
The Cage Monstro II The Adversary Gish

Double Trouble Edit

Boss Gurdy Jr.
Boss The Haunt
Boss The Wretched
Boss The Husk
(Double Trouble)

Gurdy Jr.

(Double Trouble)

The Haunt

(Double Trouble)

The Wretched

(Double Trouble)

The Husk

NecropolisEdit

Boss The Bloat
Boss The Carrion Queen
Boss The Wretched
The Bloat The Carrion Queen Mask of Infamy The Wretched

Double TroubleEdit

Boss Dark One
Boss Blighted Ovum
(Double Trouble)

Dark One

(Double Trouble)

Blighted Ovum

The Depths and NecropolisEdit

Boss The Gate
Boss Loki
Boss War
The Gate Loki War

Floor 2Edit

The Depths and NecropolisEdit

Boss Mom
Mom

Chapter 4Edit

Floor 1Edit

The WombEdit

Boss Mr. Fred
Boss Scolex
Boss Teratoma
Mr. Fred Scolex Teratoma

Double TroubleEdit

Boss The Cage
Boss Gurdy
Boss The Fallen
Boss The Gate
Boss Loki
(Double Trouble)

The Cage

(Double Trouble)

Gurdy

(Double Trouble)

The Fallen

(Double Trouble)

The Gate

(Double Trouble)

Loki

UteroEdit

Boss Blastocyst
Boss Teratoma
Boss Daddy Long Legs
Boss Triachnid
Blastocyst Teratoma Daddy Long Legs Triachnid

The Womb and UteroEdit

Boss Mama Gurdy
Boss Death
Boss Conquest
Boss The Bloat
Boss Lokii
Mama Gurdy Death Conquest The Bloat Lokii

Floor 2Edit

The Womb and UteroEdit

Boss Mom's Heart
Boss It Lives
Mom's Heart It Lives

Chapter 5Edit

SheolEdit

Boss Satan
Satan

The CathedralEdit

Boss Isaac (Boss)
Isaac

|-|

Chapter 6Edit

The ChestEdit

Boss Blue Baby
???

Dark RoomEdit

Boss The Lamb
The Lamb

Golden Door BossEdit

Boss Mega Satan
Mega Satan

UniversalEdit

Universal Bosses are those which may appear at the end of floors 1-5 and 7, replacing a boss from the pool for that environment.

Boss The Fallen
Boss The Headless Horseman
The Fallen The Headless Horseman

Devil and Angel RoomEdit

Devil RoomEdit

Boss Krampus
Krampus

Angel RoomEdit

Boss Angel
Boss Angel2
Uriel Gabriel

Mini-BossesEdit

Mini-BossesEdit

Mini-bosses can be encountered on any floor, and will appear on post-Womb/Utero floors as regular enemies. Unlike with regular bosses, there is no special door leading to a mini-boss room, meaning that there is no way to tell whether a room is inhabited with a mini-boss unless the player is in possession of an item that reveals map icons. Once in a mini-boss room, the player cannot escape through means of bombing the door, as it will be boarded off.

Each of these mini-bosses has specific drops, that are consumables or a pedestal item (less frequently).
In a room containing multiple mini-bosses, only the last one will drop something, allowing you to choose what drop you would want by killing a certain mini-boss last.

All mini-bosses are based on the Seven Deadly Sins.

Boss Envy
Boss Gluttony
Boss Wrath
Envy Gluttony Wrath
Boss Pride
Boss Lust
Boss Greed
Pride Lust Greed
Boss Sloth
Sloth

These monsters can also spawn much stronger alternatives, known as Super Sins.

Boss Super Envy
Boss Super Gluttony
Boss Super Wrath
Super Envy Super Gluttony Super Wrath
Boss Super Pride
Boss Super Lust
Boss Super Greed
Super Pride Super Lust Super Greed
Boss Super Sloth
Super Sloth

There is also an Ultra variant of Pride, portraying Edmund and Florian

Boss Ultra Pride
Ultra Pride

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