When the Lamb broke the fourth seal, I heard the voice of the fourth living creature saying, “Come.” I looked, and behold, an ashen horse; and he who sat on it had the name Death; and Hades was following with him. Authority was given to them over a fourth of the earth, to kill with sword and with famine and with pestilence and by the wild beasts of the earth. -Revelation 6:7-8

Boss Death
Found In
The Womb


Dropped Items
Ball of Bandages

Cube of Meat

Unlocked By
Defeat Mom for the first time

Death is a boss that can appear in The Womb or Utero. He is one of the four Harbingers, and the horseman of Chapter 4.


Phase 1

  • Death spawns Four scythes that stay stationary for a few seconds, then home in on the player.
  • Uses The Hourglass to slow the player down.

Phase 2

  • After enough damage is dealt, Death will dismount his horse for it to constantly charge throughout the room.
  • It is at this point where the horse becomes an enemy... It will keep charging until you have gotten its HP to zero; even if Death was already vanquished.
  • Death will occasionally spawn Knights.

Champion VersionsEdit

  • Black: In his first form, he summons Kamikaze Leeches instead of using the Hourglass. He spawns red maws rather than Knights when he dismounts his horse.


  • Death is one of the Four Horsemen of the Apocalypse.
  • Death's scythe attack is a homage to Castlevania's recurring boss, Death. Both summon four scythes that stay put for a few seconds, then home in on the player.
  • Death is the only enemy to use a status effect on Isaac.
Bosses Boss Monstro
Basement MonstroGeminiDingleLarry Jr.The Duke of FliesGurglingsFistulaStevenFamine
Cellar Gurdy Jr.PinWidowBlighted OvumThe HauntDingleLarry Jr.The Duke of FliesGurglingsFistulaFamine
The Caves ChubGurdyGurdy Jr.Mega MawMega FattyDark OneC.H.A.D.Pestilence
Catacombs The HollowThe HuskPeepPolycephalusThe Carrion QueenThe WretchedDark OnePestilence
The Depths The CageMonstro IIThe AdversaryThe GateLokiGishWarMom
Necropolis The BloatThe Carrion QueenMask of InfamyThe WretchedThe GateLokiWarMom
The Womb Mr. FredScolexTeratomaMama GurdyThe BloatLokiiDeathConquestMom's HeartIt Lives
Utero BlastocystDaddy Long LegsTeratomaMama GurdyThe BloatLokiiTriachnidDeathConquestMom's HeartIt Lives
Sheol The FallenSatan
Dark Room The LambMega Satan
Cathedral Isaac
The Chest ???Mega Satan
Devil Room Krampus
Angel Room Angel
Levels 1-5/7 The FallenThe Headless Horseman
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