Boss Mom
Found In
Dropped Items
The Polaroid, The Negative

(Before unlocking, Standard Boss Pool)

Unlocked By
Default Boss

Isaac's Mom is the boss found in The Depths II and is the final boss for the game's prologue. She is a delusional woman who believes that the hallucination she hears telling her to murder her son is the voice of God.

Behavior Edit

Mom's fight takes place in the entirety of the room. Four Boss Room doors will emerge on all four sides of the room, and Mom can attack from any of these doors. She can stomp on Isaac, which is telegraphed by a growing shadow and her screaming. All of her attacks will deal a full heart of damage. She can only be hurt by hitting her directly when she exposes her foot, eye, flesh or hand.

Standing too close to the doors will result in Mom striking with her hand. If the player isn't in reach and she isn't using her foot stomp attack, a piece of flesh will bulge from the doors and spawn various enemies. Occasionally, she may stick her eye out of the door which is harmless and vulnerable to being attacked by Isaac.

The Bible Edit

The Bible Icon Using The Bible item during the Mom boss fight will kill her instantly and unlock The Halo item.

Champion Variants Edit

Blue Mom Edit

This variant summons more often and only summons various types of enemies added in the Wrath of The Lamb expansion for the original game.

Red Mom Edit

This variant does not summon at all, and instead constantly uses her foot stomp. Her eyes can shoot three blood shots at the player when they emerge and she uses her hand much more often. This form may be triggered at will when fighting her normal form by using the Mom's Bra item during the fight.

Notes Edit

Using The High Priestess card during the fight with mom, will result in isaac being stomped instead of the enemy with the highest health.


Bosses Boss Monstro
Basement MonstroGeminiDingleLarry Jr.The Duke of FliesGurglingsFistulaStevenFamine
Cellar Gurdy Jr.PinWidowBlighted OvumThe HauntDingleLarry Jr.The Duke of FliesGurglingsFistulaFamine
The Caves ChubGurdyGurdy Jr.Mega MawMega FattyDark OneC.H.A.D.Pestilence
Catacombs The HollowThe HuskPeepPolycephalusThe Carrion QueenThe WretchedDark OnePestilence
The Depths The CageMonstro IIThe AdversaryThe GateLokiGishWarMom
Necropolis The BloatThe Carrion QueenMask of InfamyThe WretchedThe GateLokiWarMom
The Womb Mr. FredScolexTeratomaMama GurdyThe BloatLokiiDeathConquestMom's HeartIt Lives
Utero BlastocystDaddy Long LegsTeratomaMama GurdyThe BloatLokiiTriachnidDeathConquestMom's HeartIt Lives
Sheol The FallenSatan
Dark Room The LambMega Satan
Cathedral Isaac
The Chest ???Mega Satan
Devil Room Krampus
Angel Room Angel
Levels 1-5/7 The FallenThe Headless Horseman
Community content is available under CC-BY-SA unless otherwise noted.