Mr. Fred
Boss Mr. Fred
Found In
The Womb
Dropped Items
Boss Pool
Unlocked By

Mr. Fred is a boss found in the Womb or the Utero. He always appears in a double sized room.


Mr. Fred stays in the center of the room throughout the whole fight, occasionally burrowing underground for brief periods. He will not chase the player.


Mr. Fred has a number of different attacks.

  • Mr. Fred shoots four long-range blood tears in the cardinal directions around him. These tears leave red creep and will burst at the end of their range into a larger pool of creep. This move is telegraphed and not instant.
  • Mr. Fred burrows underground briefly and pops back up in his original position, firing eight blood tears around him.
  • Mr. Fred makes a gesture and one of the four Homunculus on the side of the room will break free and chase Isaac.
  • Mr. Fred Spawns a Fred which immediately burrows underground.

Champion VersionsEdit


  • Most of Mr. Fred's attacks cannot reach the sides of the room, making them relatively safe. If you have a long enough attack range, you can remain in that "safe zone" for the entire fight and only have to deal with the occasional unchained minion and his Fred summons.


  • Mr. Fred is actually just a giant baby with the medical condition, "Harlequin Ichthyosis".
  • Mr. Fred is the only boss that receives its own double room besides Mega Satan. The only other instance of a boss room being twice as long occurs during Double Trouble.


Bosses Boss Monstro
Basement MonstroGeminiDingleLarry Jr.The Duke of FliesGurglingsFistulaStevenFamine
Cellar Gurdy Jr.PinWidowBlighted OvumThe HauntDingleLarry Jr.The Duke of FliesGurglingsFistulaFamine
The Caves ChubGurdyGurdy Jr.Mega MawMega FattyDark OneC.H.A.D.Pestilence
Catacombs The HollowThe HuskPeepPolycephalusThe Carrion QueenThe WretchedDark OnePestilence
The Depths The CageMonstro IIThe AdversaryThe GateLokiGishWarMom
Necropolis The BloatThe Carrion QueenMask of InfamyThe WretchedThe GateLokiWarMom
The Womb Mr. FredScolexTeratomaMama GurdyThe BloatLokiiDeathConquestMom's HeartIt Lives
Utero BlastocystDaddy Long LegsTeratomaMama GurdyThe BloatLokiiTriachnidDeathConquestMom's HeartIt Lives
Sheol The FallenSatan
Dark Room The LambMega Satan
Cathedral Isaac
The Chest ???Mega Satan
Devil Room Krampus
Angel Room Angel
Levels 1-5/7 The FallenThe Headless Horseman
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