| Catacombs (can also be Double Trouble)
Double Trouble in: Necropolis Depths Womb
Polycephalus's attacks consist of burrowing underground and then attacking Isaac in a variety of ways.
- It may spray out a barrage of tears towards the player.
- It may fire a spread-shot of three tears at the player.
- It may summon a round worm.
- It may shoot out eight tears around him.
- Polycephaly is the condition of having more than one head.
- On Catacombs XL, it is possible to fight Polycephalus in both boss fights.
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