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Shops sell various items in exchange for pennies. Shops start at level 0 and only sell 2 consumables. They can be upgraded through the Donation Machine, which can be commonly found in the shops and sometimes in an Arcade. Each level increase adds to the shop's background and affects how many items are available.

Level    Coins
Shop stock
0 0 2 consumables available for sale
1 20 2 consumables and 1 pedestal item available for sale
2 100 3 consumables and 1 pedestal item available for sale
3 200 3-4 consumables and 1-2 pedestal items available for sale (always 5 total items)
4 600 4-5 consumables and 1-2 pedestal items available for sale (always 6 total items)

Shops can sell Hearts for 3 pennies. They can also sell Soul Hearts, Bombs, Keys, Battery Charges, Pills, and Tarot Cards for 5 pennies each.
One of the biggest draws of the shop are the items that they'll sell for 15 pennies. A list of items that can be sold can be found here.
Randomly, the prices will be cheaper and in red. Hearts will be 2 pennies, other pickups will be 3 pennies, and the items will be 7 pennies. The Steam Sale item always makes all prices cheaper.
Using a Credit Card in the shop will make all items available for free.
Having the trinket Store Credit will cause all items to be available for $0 but will be consumed upon one purchase.
Using the Rune of Jera creates a free copy of all pickups, even if you haven't purchased them.
You must use a key to open the shop, unless there's a Secret Room/Super Secret Room adjacent, in which case you can bomb your way into the store from it and leave without spending a key. The "Curse of the Maze" will also allow the chance of entry without spending of a key. However, its door is the same as the Library, and if you have no Items that make it otherwise, its symbol will be a key in the minimap.
Shops also have a chance of being replaced by a miniboss room containing Greed or Super Greed.

30px Rooms 30px

Boss Room Icon
Boss Room
Mini-Boss Room Icon
Mini-Boss Room
Treasure Room Icon
Treasure Room
Shop Icon
Arcade Icon
Challenge Room Icon
Challenge Room
Boss Challenge Room Icon
Boss Challenge Room
Curse Room Icon
Curse Room
Sacrifice Room Icon
Sacrifice Room
Secret Room Icon
Secret Room
Super Secret Room
Library Icon
Devil Room Icon
Devil Room
Angel Room Icon
Angel Room
Vault Icon
Dice Room Icon
Dice Room
30px Bedroom2 Icon
Boss Rush
Crawl Space
Black Market
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