The Adversary
Boss The Adversary
Found In
The Depths
Dropped Items
Boss Pool
Unlocked By

The Adversary is the posthumous version of Dark One, and is one of the bosses that appear in Chapter 3.


  • Darkens the room.
  • Quickly charges a homing Brimstone in any cardinal direction if Isaac is in line of fire. This is telegraphed with a very low pitched growl.
  • Flies off-screen and plummets down a few seconds later, creating a shock-wave that throws up damaging terrain (like The Cage) that subsides when it reaches the radius of roughly three tiles.
  • Occasionally summons Spiders.


  • His homing Brimstone can best be avoided by not moving too far away from him, so as soon as he starts charging it, the player can quickly turn around him about 90 degrees, which can be done much quicker the closer Isaac is to The Adversary.


  • "The adversary" is one of the ways that the original Hebrew word "ha-satan" can be translated.


Bosses Boss Monstro
Basement MonstroGeminiDingleLarry Jr.The Duke of FliesGurglingsFistulaStevenFamine
Cellar Gurdy Jr.PinWidowBlighted OvumThe HauntDingleLarry Jr.The Duke of FliesGurglingsFistulaFamine
The Caves ChubGurdyGurdy Jr.Mega MawMega FattyDark OneC.H.A.D.Pestilence
Catacombs The HollowThe HuskPeepPolycephalusThe Carrion QueenThe WretchedDark OnePestilence
The Depths The CageMonstro IIThe AdversaryThe GateLokiGishWarMom
Necropolis The BloatThe Carrion QueenMask of InfamyThe WretchedThe GateLokiWarMom
The Womb Mr. FredScolexTeratomaMama GurdyThe BloatLokiiDeathConquestMom's HeartIt Lives
Utero BlastocystDaddy Long LegsTeratomaMama GurdyThe BloatLokiiTriachnidDeathConquestMom's HeartIt Lives
Sheol The FallenSatan
Dark Room The LambMega Satan
Cathedral Isaac
The Chest ???Mega Satan
Devil Room Krampus
Angel Room Angel
Levels 1-5/7 The FallenThe Headless Horseman
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