The Gate
Boss The Gate
Found In
The Depths
Dropped Items
Boss Room

The Gate is a new boss found in The Depths.


  • Shoots 10 giant blood tears which rotate in a circular pattern and expand outwards, similar to Mega Maw's fire attack.
  • Spawns up to 3 leapers.
  • If two or more leapers are alive, The Gate might fire a Brimstone laser that will connect between each Leaper. This kills the leapers, unless they are off screen.

Trivia Edit

  • Upon death, a small Isaac head can be seen poking out of its corpse before it explodes. Two glowing white eyes are seen in it's mouth throughout the fight, which may be the Isaac head.
  • The Gate is the posthumous version of Mega Maw, but resembles a giant Host.



Bosses Boss Monstro
Basement MonstroGeminiDingleLarry Jr.The Duke of FliesGurglingsFistulaStevenFamine
Cellar Gurdy Jr.PinWidowBlighted OvumThe HauntDingleLarry Jr.The Duke of FliesGurglingsFistulaFamine
The Caves ChubGurdyGurdy Jr.Mega MawMega FattyDark OneC.H.A.D.Pestilence
Catacombs The HollowThe HuskPeepPolycephalusThe Carrion QueenThe WretchedDark OnePestilence
The Depths The CageMonstro IIThe AdversaryThe GateLokiGishWarMom
Necropolis The BloatThe Carrion QueenMask of InfamyThe WretchedThe GateLokiWarMom
The Womb Mr. FredScolexTeratomaMama GurdyThe BloatLokiiDeathConquestMom's HeartIt Lives
Utero BlastocystDaddy Long LegsTeratomaMama GurdyThe BloatLokiiTriachnidDeathConquestMom's HeartIt Lives
Sheol The FallenSatan
Dark Room The LambMega Satan
Cathedral Isaac
The Chest ???Mega Satan
Devil Room Krampus
Angel Room Angel
Levels 1-5/7 The FallenThe Headless Horseman
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